Studies
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SyNergy: Published Datasets8
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Christian Haass8
Stephan Müller5
Stefan Lichtenthaler5
Mikael Simons4
Martin Dichgans3
Arthur Liesz3
Martina Schifferer3
Matthias Brendel3
Günter Höglinger2
Martin Kerschensteiner2
Dominik Paquet2
Fabian Theis2
Ali Ertürk2
Nikolaus Plesnila2
Nicolai Franzmeier2
Johannes Levin2
Robert Perneczky2
Özgün Gökçe2
Dieter Edbauer1
Jochen Herms1
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8
Studies visible to you, out of a total of 10
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer's disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is still unknown. Another microglial-expressed AD risk factor is catalytically inactive rhomboid 2 (iRhom2, RHBDF2), which binds to and acts as a non-catalytic subunit of the metalloprotease ADAM17. A potential role in TREM2 proteolysis is not ...
