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The conserved human secreted glycoprotein Clusterin (aka Apolipoprotein-J, ApoJ) is an abundant component of body fluids such as blood plasma and cerebrospinal fluid. Clusterin is thought to function as an extracellular molecular chaperone stabilizing misfolded proteins in solution. In addition, Clusterin forms lipoprotein complexes and fractions with HDL particles in plasma. Variants of the Clusterin gene constitute the third most important genetic risk factor for late-onset Alzheimer's disease. ...

The conserved human secreted glycoprotein Clusterin (aka Apolipoprotein-J, ApoJ) is an abundant component of body fluids such as blood plasma and cerebrospinal fluid. Clusterin is thought to function as an extracellular molecular chaperone stabilizing misfolded proteins in solution. In addition, clusterin forms lipoprotein complexes and fractions with HDL particles in plasma. Variants of the clusterin gene constitute the third most important risk factor for late-onset Alzheimer's disease. To ...