Distinct molecular profiles of skull bone marrow in health and neurological disorders.
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BiBTeXThe bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.
SEEK ID: http://lmmeisd-2.srv.mwn.de/publications/85
PubMed ID: 37562402
DOI: 10.1016/j.cell.2023.07.009
Projects: SyNergy: Published Datasets
Publication type: Journal
Journal: Cell
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Created: 2nd Dec 2024 at 11:58
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Projects: SyNergy: Published Datasets, SyNergy: Unpublished Datasets
Institutions: LMU Klinikum
Please visit the 'Related items' tab within the profile page to explore associated studies in more detail.
Projects: SyNergy: Published Datasets, SyNergy: Unpublished Datasets
Institutions: LMU Klinikum
Please visit the 'Related items' tab within the profile page to explore associated studies in more detail.
Projects: SyNergy: Published Datasets, SyNergy: Unpublished Datasets
Institutions: Helmholtz Munich
Please visit the 'Related items' tab within the profile page to explore associated studies in more detail.
Projects: SyNergy: Published Datasets, SyNergy: Unpublished Datasets
Institutions: LMU Klinikum
Please visit the 'Related items' tab within the profile page to explore associated studies in more detail.
Projects: SyNergy: Published Datasets
Institutions: LMU
Please visit the 'Related items' tab within the profile page to explore associated studies in more detail.
Neurological diseases are on the rise – and as societies age, they affect an ever-increasing number of people, not only in Europe, but worldwide.
The Munich Cluster for Systems Neurology (SyNergy) investigates how complex neurological diseases such as Alzheimer's disease, stroke, and multiple sclerosis develop. Even though these diseases differ in their clinical manifestations, overlapping mechanisms are involved in their development. For example, the immune system gets activated in dementia, ...
Projects: SyNergy: Published Datasets, SyNergy: Unpublished Datasets
Web page: https://www.synergy-munich.de
This project serves as a centralized repository for omics datasets published by research groups within the SyNergy Cluster. It encompasses investigations such as proteomics and transcriptomics, which are further divided into individual studies led by SyNergy members. Each study is linked to relevant publications, assays and data files (with links to external repositories).
To explore investigations and their associated studies in more detail, please visit the 'Related items' tab on the Project ...
Programme: Munich Cluster for Systems Neurology (SyNergy)
Public web page: Not specified
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related ...
Submitter: Aditi Methi
Investigation: Transcriptomics (Published)
Assays: Expression profiling: scRNA-seq (mouse) + Bulk RNA-seq (mouse)
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related ...
